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Recently, more attention has been given to incorporating inorganic NPs such as gold and magnetic NPs with both imaging and therapeutic capabilities into polymer and lipid based NPs for improved therapy and imaging in cancer treatment.
In addition, this emerging field of nanomedicine requires better understanding of the interface between nanotechnology and medicine. Devika Chithrani, Polyethylene Glycol (PEG) Functionalized Nanoparticles for Improved Cancer Treatment, Reviews in Nanoscience and Nanotechnology, 3, 20-30 (2014).
These fundamental studies will facilitate building of better NP-based platforms for improved results in the future cancer care of patients. Chithrani, Integration of Peptides for Enhanced Uptake of PEGylayed Gold Nanoparticles, Journal of Nanoscience and Nanotechnology, 15, 1-7 (2014). In treating cancer, radiation therapy and chemotherapy remain as the most widely used treatment options. Recent developments in cancer research show that the incorporation of gold nanostructures into those protocols have enhanced tumor cell damage. My research program also involves the use of gold nanostructures as a versatile platform for integration of many therapeutic options towards optimizing combinational therapy platform in the battle against cancer.
My research program is designed to improve the understanding of the bio-nano interface. Chithrani, Polyethylene Glycol Density and Length Affects Nanoparticle Uptake by Cancer Cells, Journal of Nanomedicine Research, 1, 1-6 (2014). Better knowledge of the nano-bio interface would lead to better tools for diagnostic imaging and therapy.