What is the most sedating antidepressant
This compound has a different three-ring structure from imipramine.It was not originally targeted for the treatment of depression.The drug's tendency to induce manic effects was "later described as 'in some patients, quite disastrous'".Geigy later became Ciba-Geigy and eventually Novartis. The compounds described share a tricyclic backbone different from the backbone of the TCA amitriptyline.Merck introduced the second member of the TCA family, amitriptyline (Elavil), in 1961.Research chemists quickly began to explore other derivatives of chlorpromazine.The first TCA reported for the treatment of depression was imipramine, a dibenzazepine analogue of chlorpromazine code-named G22355.They are named after their chemical structure, which contains three rings of atoms.
The paradoxical observation of a sedative inducing mania led to testing with depressed patients.The first trial of imipramine took place in 1955 and the first report of antidepressant effects was published by Swiss psychiatrist Roland Kuhn in 1957. patent 3,074,931 issued 1963-01-22 by assignment to Smith Kline & French Laboratories.Although TCAs are sometimes prescribed for depressive disorders, they have been largely replaced in clinical use in most parts of the world by newer antidepressants such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs) and norepinephrine reuptake inhibitors (NRIs).Adverse effects have been found to be of a similar level between TCAs and SSRIs.
The TCAs were developed amid the "explosive birth" of psychopharmacology in the early 1950s.
The story begins with the synthesis of chlorpromazine in December 1950 by Rhône-Poulenc's chief chemist, Paul Charpentier, from synthetic antihistamines developed by Rhône-Poulenc in the 1940s.